Human dendritic cell models
Dendritic cells are considered the most potent antigen presenting cells of the immune system and are responsible for activation of the adaptive immune system in response to infections (figure 1). Dendritic cells are key regulators of the immune system in immunological disorders such as autoimmune and allergic diseases and are thus promising target cells for therapeutic treatment of these disorders. Bioneer's hDC models are thus highly suited for testing of compounds supposedly acting on DC-level targets.
Figure 1: Activation of the adaptive immune system by dendritic cells (click figure for larger image)
Our hDC models are applied under mainly two settings:
- Assessment of the overall immune modulation. This mostly applies to immune stimulation or modulating drugs or complex mixtures of e.g. natural extracts or microorganisms. The test reagent is added to immature DCs, and the response from the DC is measured in order to predict the effect of the reagent under in vivo conditions.
- Analyses of a compound or other reagent to suppress a specific immune response using our proprietary immune inducing cocktails (Th1, Th2 and Th17 responses). This mostly applies to screening of biologics, small molecule drugs or inhibitors of specific intracellular targets and pathways.