Protein Manufacturing

Small-scale protein production and downstream processing

Bioneer addresses a client's needs for limited amounts of recombinant proteins, e.g. during the discovery phase and preclinical phase of biologics development.

Different proteins require different production systems, and Bioneer offers to test a client's protein in a variety of microbial and mammalian production systems and, subsequently, to optimise the production system by genetic and physiological means. Specifically, Bioneer offers access to a proprietary microbial production system (P170) through licensing of intellectual property covering the expression system (promoter, signal sequence and an optimised host cell) as well as fermentation technology.

Bioneer has downstream processing capability at gram scale and offers purification of proteins.

Finally, Bioneer offers small-scale contract production of recombinant proteins compliant with Good Manufacturing Practise.


	Development of production organism	Genetic optimisation and scale up of fermentation	Contract protein production
Microbial expression technology	L. lactis P 170 system E. coli system	L lactis process optimisation E. coli process optimisation	L. lactis system E. coli system
Mammalian expression technology	Mammalian expression system	Mammalian process optimisation	Mammalian contract production
Downstream processing	Analytical scale protein purification	Analytical to gram scale purification	Gram scale purification
Formal documentation	Quality documentation	Delivery of SOP	GMP compliant documentation